Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936
نویسندگان
چکیده
منابع مشابه
Intellect and cognitive performance in the Lothian Birth Cohort 1936.
Investment personality traits are thought to positively affect cognitive performance in old age, even after controlling for prior cognitive ability. In the Lothian Birth Cohort 1936 (N = 1,091), a cross-lagged model tested for reciprocal effects of the investment trait Intellect on verbal fluency, an indicator of crystallized intelligence, at age 70 and 73 years, while adjusting for general IQ ...
متن کاملCohort profile: the Lothian Birth Cohorts of 1921 and 1936.
This cohort profile describes the origins, tracing, recruitment, testing and follow-up of the University of Edinburgh-based Lothian Birth Cohorts of 1921 (LBC1921; N = 550) and 1936 (LBC1936; N = 1091). The participants undertook a general intelligence test at age 11 years and were recruited for these cohorts at mean ages of 79 (LBC1921) and 70 (LBC1936). The LBC1921 have been examined at mean ...
متن کاملBrain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936☆
Elevated glucocorticoid (GC) levels are hypothesized to be deleterious to some brain regions, including white matter (WM). Older age is accompanied by increased between-participant variation in GC levels, yet relationships between WM integrity and cortisol levels in older humans are underexplored. Moreover, it is unclear whether GC-WM associations might be general or pathway specific. We analyz...
متن کاملADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936.
The non-synonymous mutations arg16gly (rs1042713) and gln27glu (rs1042714) in the adrenergic β-2 receptor gene (ADRB2) have been associated with cognitive function and brain white matter integrity. The current study aimed to replicate these findings and expand them to a broader range of cognitive and brain phenotypes. The sample used is a community-dwelling group of older people, the Lothian Bi...
متن کاملPersonality, health, and brain integrity: the Lothian birth cohort study 1936.
OBJECTIVE To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. METHOD Participants from the Lothian Birth Cohort 1936 completed the...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2018
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.05.029